SafeSpot is a pioneering, 24/7 peer-led virtual overdose detection and prevention hotline designed to keep people safe while they use drugs alone. Through confidential phone support, trained operators with lived experience stay on the line during use and, if a caller becomes unresponsive, activate emergency help based on a prearranged safety plan — a model rooted in dignity, harm reduction, and human connection. Originally launched in Massachusetts as the Overdose Prevention Helpline, SafeSpot now operates nationally, has supported tens of thousands of use events, and builds pathways for operators from lived experience to professional careers in harm reduction.